[Effect of cortisome on monocyte "disappearance" from the blood]

The effect of cortisone on monocyte "disappearance" from peripheral blood of guinea pigs sensibilized with live S. abortus ovis culture and showing positive skin-allergic reaction with allergen of the same salmonella was studied. It was established that in case cortisone is applied in a dose of 22 mg per guinea pig intramusculary 3 or 1 h before or simultaneously with intravenous injection of homologous allergen, it blocks the allergen's effect on monocyte "disappearance", i.e. the number or monocytes in cortisone treated animals does not change, while their number in the control animals (not treated with cortisone) decreases considerably. The possible blocking effect mechanisms of cortisone on the specific allergen action are discussed.