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Lymphokine-induced changes in macrophage transmembrane electrical potentials
Biomedicine / [Publiee Pour L'A.A.I.C.I.G.]
|December 1, 1979
Abstract:
Intracellular electrical potentials have been measured in nonactivated and immunologically-activated macrophages obtained from the peritoneal cavities of mice. Normal macrophage potentials were established and found to become significantly more electronegative after in vitro exposure for 10 minutes to a lymphokine-containing supernatant which induced macrophage activation. This approach may reflect very early concomitants of such activation and is also useful in the study of other immunologic systems.