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Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
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Cushing Syndrome II: Pathophysiology

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Updated: Jul 20, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
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Published on: April 25, 2016

Hydrocortisone choleresis in the dog.

V Macarol, T Q Morris, K J Baker

    The Journal of Clinical Investigation
    |September 1, 1970
    PubMed
    Summary

    Hydrocortisone sodium succinate induces bile flow (choleresis) in dogs by affecting liver cells. This effect is independent of bile salts and suggests a novel bile formation pathway.

    Area of Science:

    • Gastroenterology
    • Hepatology
    • Pharmacology

    Background:

    • Bile formation is crucial for digestion and detoxification.
    • The mechanisms of choleretic agents, particularly corticosteroids, are not fully understood.
    • Hydrocortisone's effect on bile production requires further investigation.

    Purpose of the Study:

    • To investigate the choleretic effect of hydrocortisone sodium succinate in vivo.
    • To elucidate the mechanism by which hydrocortisone influences bile flow.
    • To determine if the choleretic response is mediated by bile salts or hepatocellular mechanisms.

    Main Methods:

    • Unanesthetized dogs with Thomas duodenal cannulae were used for direct bile collection.
    • Hydrocortisone sodium succinate was administered via infusion.

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  • Bile flow, electrolyte output, erythritol clearance, and sulfobromophthalein excretion were measured.

    • Main Results:

    • Hydrocortisone infusion significantly increased bile flow (average 68%) and electrolyte output.
    • The choleretic response was independent of and additive to sodium taurocholate.
    • Erythritol clearance increased with bile flow, suggesting a hepatocellular site of action.

    Conclusions:

    • Hydrocortisone sodium succinate induces choleresis through a mechanism likely involving hepatocellular pathways.
    • The findings suggest a bile salt-independent canalicular bile formation mechanism.
    • This study provides insights into the complex regulation of bile production.