[Luteal insufficiency. Histoclinical and biological correlations]

Luteal insufficiency, an entity accepted with difficulty, is responsible for 3.5 p. 100 of cases of infertility and 35 p. 100 of early abortions. This study, carried out in 328 women with an average age of 29 years, involved clinical and histological features, as well as the estimation of plasma levels and endometrial receptors of ovarian steroids. Three broad histological patterns emerged:--luteal insufficiency associated with oestrogenic insufficiency indicative of overall ovarian deficiency;--luteal insufficiency with functional dysmaturation indicative of deficient or delayed luteal function, with or without persistence of excessively high oestrogen activity,--luteal insufficiency related to the short life of the corpus luteum which stops on the 20th day. Relationships between histological findings, the measurement of receptors and plasma estimations are discussed and precise analysis of endometrial biopsies must be considered as one of the best test of luteal insufficiency.