Experimental hydrocephalus of the rat, produced by cisternal injection of kaolin-solution (author's transl)

Experimental hydrocephalus was produced in rats in high percentage, by direct injection of kaolin-solution into the cisterna magna under a operating microscope. Rats with hydrocephalus showed retarded development of the body. The skull enlarged round and became so thin, that the cortical vessels were observed through the skull. The brain showed marked internal hydrocephalus, retaining cerebrospinal fluid passage in the ventricular system, but there was an obstruction at the ambient cistern and the basal cistern. Review of the literature dealing with the methods to produce acquired hydrocephalus showed that this is the first report of experimental hydrocephalus of the rat produced by injecting kaolin-solution.