Related Experiment Video
Updated: Aug 14, 2026

Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes
Published on: May 8, 2016
Development of intestinal host defense mechanisms and the passive protective role of human milk
Abstract:
In this review of development of host defense mechanisms of the gastrointestinal tract, I have attempted to develop the concept of a mucosal barrier to the uptake of intestinal antigens and microorganisms. Alterations in development of immunologic defense and non-immunologic defenses results in an increased vulnerability for clinical disease in the newborn (premature) infant. The passive role of human milk in promoting intestinal maturation and protecting the newborn gut from pathologic penetration of macromolecules is discussed. It was predicted that many, as yet undiscovered factors, will be reported in future years to further underscore the importance of human milk in perinatal host defense. Immediate and delayed disease states resulting from an altered defense were considered.
More Related Videos
Related Concept Videos
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
Defense Mechanism Against Infection
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
Introduction to Innate and Adaptive Immunity
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Introduction to the Human Microbiota
Development of Human Microbiota

