Related Experiment Video
Updated: Aug 12, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
Published on: July 22, 2011
Post-traumatic immunosuppression is due to activation of suppressor T cells
Abstract:
Severe immunosuppression occurs after major thermal burns, accidental injuries, and extensive surgical operations, and probably contributes substantially to patient morbidity and mortality. The mechanism of immunosuppression is unknown and attempts to explain it are contradictory. The contradictions can be resolved by assuming the activation by injury of the suppressor T-cell system, which is involved in normal immunoregulation. If this is true, then generalised, non-specific attempts to bolster the immune response in these patients may be inappropriate.
Related Concept Videos
Cell-mediated Immune Responses
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Tumor Immunotherapy

