[Immunochemical characteristics of artificial antigens with Salmonella O-determinants 4 and 9]

Two new synthetic high-molecular protein-free O-antigens have been obtained. These O-antigens are copolymers of synthetic disaccharides with acrylamide. The copolymers of alpha-allylglycosides, abequosyl-(alpha 1----3]-mannopyranose and tyvelosyl-(alpha 1----3)-mannopyranose, with acrylamide have been shown to possess, respectively, the specificity of immunodominant O-factors 4 and 9 characteristic of Salmonella serogroups B and D1. The synthetic O-antigens have proved to possess higher capacity for binding antibodies in the precipitation test and the hemagglutination inhibition test than the corresponding lipopolysaccharides.