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Red blood cell transfusion therapy.

M B Dahlke

    The Medical Clinics of North America
    |May 1, 1984
    PubMed
    Summary

    This study reviews alloantibodies causing rapid red blood cell destruction and discusses pretransfusion testing, crossmatch resolution, and current transfusion practices, including indications and complications.

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    Area of Science:

    • Immunology
    • Transfusion Medicine
    • Hematology

    Background:

    • Alloantibodies can cause accelerated in vivo red blood cell destruction, leading to transfusion complications.
    • Accurate pretransfusion testing is crucial for identifying these antibodies and ensuring transfusion safety.

    Purpose of the Study:

    • To describe the characteristics of alloantibodies responsible for rapid red blood cell destruction.
    • To outline pretransfusion tests for detecting these antibodies and resolving incompatible crossmatches.
    • To discuss current red blood cell transfusion practices, indications, and potential complications.

    Main Methods:

    • Review of literature on alloantibody characteristics and their impact on red blood cell survival.
    • Description of standard pretransfusion testing protocols, including crossmatch procedures.
    • Analysis of current transfusion guidelines and reported complications.

    Main Results:

    • Alloantibodies are identified as a significant cause of accelerated in vivo red blood cell destruction.
    • Pretransfusion tests effectively detect clinically significant alloantibodies.
    • Resolution of incompatible crossmatches is achievable through various strategies.

    Conclusions:

    • Understanding alloantibody characteristics is vital for safe red blood cell transfusion.
    • Appropriate pretransfusion testing and crossmatch resolution are essential to prevent transfusion reactions.
    • Current transfusion practices aim to balance the benefits and risks of red blood cell transfusions.

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