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Articles linked to this work by shared authors, journal, and citation graph.

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[Ultrastructural changes in the cerebral cortex of an 100 1/2-year-old man].

Arkhiv anatomii, gistologii i embriologii·1990
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[Hypo- and hyperdiagnosis of senile dementia and Alzheimer's disease in psychiatric practice].

Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952)·1987
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[Ultrastructure of epileptic foci in temporal epilepsy].

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[Muli-infarct dementia].

Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952)·1985
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[Special forms of ultrastructural changes in dendrites and axons in the human and cat brain].

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[Relation between the degree of severity of the dementia and the extent of the manifestation of the pathomorphological changes in the cerebral cortex in senile dementia and Alzheimer's disease].

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Related Experiment Video

Updated: Jul 11, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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Published on: March 23, 2011

The morphological basis of age-induced memory changes.

A S Iontov, V F Shefer

    Neuroscience and Behavioral Physiology
    |September 1, 1984
    PubMed
    Summary

    This study reveals age-related changes in the human cortex, impacting memory mechanisms. Similar alterations were observed in old cats, suggesting conserved cellular changes related to aging and memory.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Gerontology

    Background:

    • Understanding the aging brain is crucial for cognitive health.
    • The morphological basis of memory mechanisms requires detailed investigation.

    Purpose of the Study:

    • To investigate age-related ultrastructural changes in the human cortex (area 40).
    • To correlate observed cortical changes with hypotheses on memory mechanisms.
    • To compare human cortical changes with those in aged animal models.

    Main Methods:

    • Layer-by-layer electron microscopy of the human cortex (area 40) from elderly individuals (78-83 years).
    • Comparative electron microscopy of the auditory cortex in old cats.
    • Analysis of cellular components including cytoplasm, neurocytes, dendrites, spines, and axons.

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    Main Results:

    • Identified significant ultrastructural changes in the human cortex of elderly individuals.
    • Observed alterations in cytoplasm, neurocytes, dendrites, spines, axons, and their terminals.
    • Found comparable changes in the auditory cortex of old cats, validating the human findings.

    Conclusions:

    • Age-related cortical changes are linked to the morphological substrate of memory.
    • These cellular alterations provide insights into the aging process and memory function.
    • The study highlights conserved cellular mechanisms of aging across species.