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Susceptibility to cancer: some examples from epidemiology
The Tokai Journal of Experimental and Clinical Medicine
|December 1, 1983
Summary
Individual susceptibility to cancer varies due to environmental factors and host characteristics. Epidemiological studies show environmental exposures significantly influence cancer development and risk modification.
Area of Science:
- Oncology
- Epidemiology
- Environmental Health
Background:
- Cancer susceptibility varies among individuals despite no known population immunity.
- Age is a significant factor in cancer development, influenced by exposure and resistance.
- Migrant studies reveal that some population-level cancer resistance may be illusory.
Purpose of the Study:
- To explore individual differences in susceptibility to cancer development.
- To investigate the role of environmental carcinogenic risk factors.
- To understand the interplay between host factors and cancer risk.
Main Methods:
- Epidemiological analysis of cancer incidence and risk factors.
- Examination of migrant population data to assess cancer patterns.
- Investigation of genetic and environmentally induced host factors.
Main Results:
- Environmental factors play a crucial role in cancer causation.
- Certain populations exhibit specific susceptibilities to tumors like nasopharyngeal and skin cancer.
- Host factors, both genetic and environmental, contribute to varying cancer susceptibility.
Conclusions:
- Abundant epidemiological evidence supports the role of environmental factors in cancer.
- Further research should explore interactions between carcinogenic factors and risk modifiers.
- Understanding host factors is key to explaining differential cancer susceptibility.