Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The vomiting patient.

J B Wyman, M R Wick

    American Family Physician
    |February 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Vomiting causes stem from two brain areas: the emesis center (EC) and chemoreceptor trigger zone (CTZ). Different drug classes target these specific vomiting pathways for effective treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pancreatic neuroendocrine neoplasms: a current summary of diagnostic, prognostic, and differential diagnostic information.

    American journal of clinical pathology·2002
    Same author

    Neuroendocrine neoplasms of the lung.

    American journal of clinical pathology·2002
    Same author

    Consensual interpretive guidelines for diagnostic immunohistochemistry.

    The American journal of surgical pathology·2001
    Same author

    Protocol for the examination of specimens from patients with carcinomas of the skin, excluding eyelid, vulva, and penis: a basis for checklists.

    Archives of pathology & laboratory medicine·2001
    Same author

    Immunohistochemical differential diagnosis of pleural effusions, with emphasis on malignant mesothelioma.

    Current opinion in pulmonary medicine·2001
    Same author

    Linear syringocystadenoma papilliferum of the thigh.

    Journal of the American Academy of Dermatology·2001
    Same journal

    For Post-stent Patients With Atherosclerotic Coronary Vascular Disease Who Are Taking an Anticoagulant, Adding Aspirin Worsens Outcomes.

    American family physician·2026
    Same journal

    Nausea and Vomiting During Pregnancy.

    American family physician·2026
    Same journal

    Metabolic Dysfunction-Associated Steatotic Liver Disease: Diagnosis and Management.

    American family physician·2026
    Same journal

    Aerobic Exercise Is the Better Exercise Modality for Knee Osteoarthritis.

    American family physician·2026
    Same journal

    Overscreening Leads to Overdiagnosis of MASLD.

    American family physician·2026
    Same journal

    Type 2 Diabetes: Outpatient Insulin Management.

    American family physician·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Gastroenterology

    Background:

    • Vomiting (emesis) is a complex reflex controlled by distinct neural pathways.
    • Understanding the neural sites of emesis is crucial for developing targeted antiemetic therapies.

    Purpose of the Study:

    • To categorize the causes of vomiting based on their neural origins.
    • To elucidate the pharmacologic mechanisms of antiemetic drugs targeting specific emetogenic pathways.

    Main Methods:

    • Review of neuroanatomy and neurophysiology of emesis.
    • Analysis of drug mechanisms of action on the emesis center (EC) and chemoreceptor trigger zone (CTZ).

    Main Results:

    • Vomiting causes are classified into two groups: those acting via the EC (e.g., anatomic disorders) and those acting via the CTZ (e.g., toxic/metabolic issues).

    Related Experiment Videos

  • Antihistamines exert antiemetic effects on the EC.
  • Phenothiazines and related drugs inhibit vomiting mediated by the CTZ.

    • Conclusions:

    • A logical pharmacologic strategy for managing vomiting can be developed by understanding the distinct roles of the EC and CTZ.
    • Targeting specific neural pathways offers a rational approach to antiemetic drug selection.