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Updated: Jul 29, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice
Published on: January 26, 2016
Computerized analysis of sleep recordings applied to drug evaluation: midazolam in normal subjects
Abstract:
Computerized analysis of polygraphic sleep recordings was carried out for the evaluation of midazolam, a benzodiazepine hypnotic. The analysis was carried out in real time on a small laboratory computer, and the output included the hypnogram and relative power profiles for the main electroencephalogram activities. Analysis showed a slight "intranight rapid eye movement rebound" during medication and reduction of sleep stage IV after withdrawal. The relative power of the delta frequency band did not change during medication or withdrawal.
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