Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beta-blockers and renal function.

R Wilkinson

    Drugs
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Beta-blockers can affect kidney function by blocking beta-receptors. While acute use generally reduces renal blood flow, chronic use effects vary by drug type, with cardioselective options showing fewer significant impacts.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Search for supersymmetry in pp collisions at √7 TeV in events with two photons and missing transverse energy.

    Physical review letters·2011
    Same author

    Study of Z Boson Production in PbPb Collisions at √S(NN)=2.76 TeV.

    Physical review letters·2011
    Same author

    Search for pair production of first-generation scalar leptoquarks in pp collisions at √s = 7 TeV.

    Physical review letters·2011
    Same author

    Search for pair production of second-generation scalar leptoquarks in pp collisions at √s = 7 TeV.

    Physical review letters·2011
    Same author

    Measurement of dijet angular distributions and search for quark compositeness in pp collisions at √s = 7 TeV.

    Physical review letters·2011
    Same author

    Dijet azimuthal decorrelations in pp collisions at √s=7 TeV.

    Physical review letters·2011
    Same journal

    Botulinum Toxin Type A for Trigeminal and Postherpetic Neuralgia: An Umbrella Review of Systematic Reviews.

    Drugs·2026
    Same journal

    Biologics and Small Molecule Inhibitors: Novel Therapeutic Strategies for Cutaneous Adverse Drug Reactions.

    Drugs·2026
    Same journal

    Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression.

    Drugs·2026
    Same journal

    Relacorilant: First Approval.

    Drugs·2026
    Same journal

    Developmental Progress and Future Potential for Inhaled Biologics in the Treatment of Respiratory Diseases.

    Drugs·2026
    Same journal

    Linerixibat: First Approval.

    Drugs·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Nephrology
    • Cardiology

    Background:

    • Kidney adrenergic receptors (alpha, beta 1, beta 2) regulate renal blood flow, renin secretion, and vasodilation.
    • Beta-blockers, differing in cardioselectivity and sympathomimetic activity, can impact renal function via intrarenal effects or reduced cardiac output/blood pressure.

    Purpose of the Study:

    • To investigate the effects of various beta-adrenergic blocking drugs on renal function.
    • To differentiate the renal effects based on drug properties like cardioselectivity and intrinsic sympathomimetic activity.

    Main Methods:

    • Review of studies examining acute and chronic administration of different beta-blockers.
    • Analysis of effects on effective renal plasma flow and glomerular filtration rate.

    Related Experiment Videos

    Main Results:

    • Acute beta-blocker administration typically reduces renal plasma flow and glomerular filtration rate, with exceptions like nadolol.
    • Chronic non-cardioselective beta-blockers decrease renal function, while cardioselective agents generally do not cause significant reductions.
    • Small increases in serum urea are observed with cardioselective drugs; nadolol's chronic oral effect remains uncertain.

    Conclusions:

    • Beta-blockers likely impair renal function primarily by blocking renal beta 2-receptors.
    • Most reported reductions in glomerular filtration rate are not clinically significant, even in impaired renal function.
    • Non-metabolized beta-blockers (atenolol, nadolol, sotalol) require dose reduction in renal failure; propranolol also needs adjustment due to active metabolites.