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Related Experiment Videos

Stress, catecholamines and beta-blockade.

J Bonelli

    Acta Medica Scandinavica. Supplementum
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Beta-blockers like propranolol and mepindolol reduce heart rate and cardiac output during mental stress. However, they may increase diastolic blood pressure, suggesting limited use in non-hypertensive individuals facing stress.

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    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology

    Background:

    • Beta-blockade is used to manage cardiovascular conditions.
    • The haemodynamic response to psychological stress is complex.

    Purpose of the Study:

    • To investigate the effects of beta-blockade (propranolol, mepindolol) on haemodynamic responses during mental arithmetic stress.
    • To assess the impact on heart rate, cardiac output, blood pressure, and plasma adrenaline.

    Main Methods:

    • Two groups of volunteers received either propranolol or mepindolol.
    • Haemodynamic parameters and plasma adrenaline were measured under basal and stress conditions (mental arithmetic).

    Main Results:

    • Propranolol and mepindolol significantly reduced stress-induced increases in heart rate and cardiac output.

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  • Propranolol slightly decreased systolic pressure but increased diastolic pressure during stress.
  • Mepindolol did not significantly alter diastolic pressure but reduced plasma adrenaline.
  • Plasma adrenaline increased significantly under stress, unaffected by propranolol but reduced by mepindolol.

    • Conclusions:

    • Beta-blockers attenuate heart rate and cardiac output responses to stress.
    • Their effect on diastolic pressure can be variable, sometimes potentiating increases.
    • Use in non-hypertensive patients should be limited to pathological stress reactions, not general stress management.