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Selective decrease in immunoreactive somatostatin in rat intermediate pituitary lobe after stalk section.

J M Saavedra, C Rougeot, F Dray

    Neuroendocrinology
    |August 1, 1983
    PubMed
    Summary
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    Somatostatin is found in the rat pituitary gland, primarily the intermediate lobe. Pituitary stalk sectioning significantly reduces intermediate lobe somatostatin, suggesting brain-originating nerve fibers transport this peptide.

    Area of Science:

    • Neuroendocrinology
    • Pituitary Gland Research

    Background:

    • Somatostatin is a peptide hormone with diverse physiological roles.
    • The distribution and origin of somatostatin within the pituitary gland are not fully understood.

    Purpose of the Study:

    • To investigate the localization and source of immunoreactive somatostatin in the rat pituitary gland.
    • To determine the impact of pituitary stalk transection on somatostatin levels in different pituitary lobes.

    Main Methods:

    • Immunohistochemical analysis of rat pituitary tissue.
    • Measurement of somatostatin peptide levels following pituitary stalk sectioning.

    Main Results:

    • Immunoreactive somatostatin was detected in the intermediate and posterior pituitary lobes of rats.

    Related Experiment Videos

  • Pituitary stalk sectioning led to an 80% decrease in somatostatin in the intermediate lobe.
  • Somatostatin levels in the posterior lobe remained unchanged after pituitary stalk sectioning.

    • Conclusions:

    • A significant portion of somatostatin in the intermediate pituitary lobe originates from nerve fibers originating in the brain.
    • The posterior pituitary somatostatin likely has a different origin or transport mechanism.