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[Drug-induced urinary lithiasis].

R J Reveillaud, M Daudon

    Presse Medicale (Paris, France : 1983)
    |October 29, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Analyzing 2,000 urinary calculi revealed rare drug constituents linked to stone formation. Despite widespread use of these medications, drug-induced urinary calculi remain uncommon.

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    Area of Science:

    • Urology
    • Analytical Chemistry
    • Pharmacology

    Context:

    • Urinary calculi analysis is crucial for understanding stone etiology.
    • Infra-red spectrophotometry is a key analytical technique for mineral and drug identification in calculi.
    • Identifying drug components in urinary stones can elucidate their formation pathways.

    Purpose:

    • To investigate the presence of rare constituents and drugs within urinary calculi.
    • To determine the potential role of identified drugs in urinary stone formation.
    • To assess the incidence of drug-induced urinary calculi.

    Summary:

    • Infra-red spectrophotometry analysis of 2,000 urinary calculi identified several drugs and rare constituents potentially responsible for stone formation.
    • Identified substances included glafenine, triamterene, co-trimoxazole, sulphaguanidine, allopurinol, phenazopyridine, flumequine, and anti-acid compounds.

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  • Despite the common use of these drugs, the study found a low incidence of drug-induced urinary calculi.

    • Impact:

    • Highlights the importance of thorough urinary calculus examination to identify iatrogenic causes.
    • Provides data on the low but potential risk of drug-induced urinary stone disease.
    • Informs clinical practice regarding the etiological investigation of urinary calculi.