[Development of tolerance to haloperidol in the rat striatum]

Microiontophoretic application of dopamine effects in the rat's striatum a dose-dependent inhibition of the glutamate-induced pulse activities. Acute systemic applications of haloperidol are able to abolish this dopamine-induced inhibition. After chronic pretreatment with haloperidol, however, acute administration of haloperidol can no longer antagonize the dopamine-induced inhibition of the pulse activity. Hence, it is likely that tolerance to haloperidol , as described in individual behavioral studies can develop also on the cellular level.