Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phenotypic genetics of complement components.

M J Hobart

    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
    |September 6, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Five new polymorphisms in the complement C7 gene and their association with C7 deficiency.

    Experimental and clinical immunogenetics·1999
    Same author

    Evolution of the terminal complement genes: ancient and modern.

    Experimental and clinical immunogenetics·1999
    Same author

    Reference typing report for complement components C6, C7 and C9 including mutations leading to deficiencies.

    Experimental and clinical immunogenetics·1999
    Same author

    The molecular basis of C6 deficiency in the western Cape, South Africa.

    Human genetics·1998
    Same author

    Complement C7 deficiency: seven further molecular defects and their associated marker haplotypes.

    Human genetics·1998
    Same author

    C7 deficiency in an Irish family: a deletion defect which is predominant in the Irish.

    Clinical and experimental immunology·1998
    Same journal

    The microlandscapes of tree trunks: the effect of lichen and tree-level characteristics on arthropod communities.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Centimetre-scale landscapes to assess the motion behaviour and cognition of gastropods and bivalves.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Intertidal microcosms of wave-swept rocky shores: ecological and physiological insights from a uniquely stressful environment.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Temporal and spatial variation in temperature and oxygen at the microscale: key niche axes for aquatic life.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Natural microcosms in ecology: fulfilling the promise of model systems?

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    Same journal

    Microbe-induced galls and plant defence: metabolite crosstalk in a co-evolutionary battle.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
    See all related articles

    Genetic analysis of complement proteins reveals variations in ten out of seventeen proteins, with C4 showing high polymorphism linked to disease susceptibility. Electrophoretic techniques elucidated gene linkages and structures.

    Area of Science:

    • Immunogenetics
    • Molecular Biology
    • Human Genetics

    Background:

    • Complement proteins are crucial for immune response.
    • Genetic variations in complement proteins can impact health and disease.
    • Electrophoretic techniques are valuable for studying protein polymorphisms.

    Purpose of the Study:

    • To investigate genetic polymorphisms in complement proteins using electrophoretic methods.
    • To determine the number of cistrons and linkage relationships for complement proteins.
    • To explore the genetic basis of complement protein variations and their association with disease.

    Main Methods:

    • Charge and size-dependent electrophoretic techniques.
    • Analysis of genetic variants across seventeen complement proteins.

    Related Experiment Videos

  • Investigating linkage of complement genes (C2, Factor B, C4) to the Major Histocompatibility Complex (MHC).

    • Main Results:

    • Ten of seventeen complement proteins exhibit genetic variants; C9 shows no variants.
    • Confirmed linkage of C2, Factor B, and C4 to the MHC.
    • Human C4 is highly polymorphic with duplicated loci and disease-associated haplotypes.
    • Identified genetic structures for C8, C6, and C7, including potential duplications and linkages.

    Conclusions:

    • Electrophoretic studies provide insights into complement system genetics and evolution.
    • Genetic variations in complement proteins, particularly C4, are linked to disease susceptibility.
    • The study highlights the complexity of complement gene organization and its evolutionary implications.