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The lung in relation to vasoactive polypeptides.

S I Said, V Mutt, E G Erdös

    Ciba Foundation Symposium
    |January 1, 1980
    PubMed
    Summary
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    The lungs metabolize peptides, forming, releasing, activating, and inactivating them. Some lung tumors ectopically secrete peptide hormones, potentially causing clinical syndromes.

    Area of Science:

    • Pulmonary Medicine
    • Biochemistry
    • Endocrinology

    Background:

    • The lungs perform metabolic functions, including the synthesis, release, activation, and inactivation of biologically active peptides.
    • Various peptides such as vasoactive intestinal peptide, bradykinin, substance P, and bombesin-like peptides are found in normal lung tissue, originating from neuroendocrine cells, neurons, or mast cells.
    • The lung's pulmonary vascular endothelium contains kininase II (angiotensin-converting enzyme), which inactivates bradykinin and activates angiotensin.

    Purpose of the Study:

    • To explore the metabolic functions of the lungs concerning peptide formation, release, activation, and inactivation.
    • To identify peptides present or formed in normal lung tissue.
    • To investigate the production and release of peptide hormones by pulmonary tumors and lesions.

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    Main Methods:

    • Review of existing literature on lung peptide metabolism.
    • Identification of peptides found in normal lung tissue and their cellular origins.
    • Analysis of the role of pulmonary vascular endothelium in peptide inactivation and activation.
    • Examination of peptide hormone secretion by pulmonary tumors and non-tumorous lesions.

    Main Results:

    • Normal lung tissue contains and metabolizes peptides including vasoactive intestinal peptide, bradykinin, substance P, and bombesin-like peptides.
    • The enzyme kininase II, located in the pulmonary vascular endothelium, is crucial for inactivating bradykinin and activating angiotensin.
    • Pulmonary tumors and certain lesions can ectopically produce and release peptide hormones not typically found in lung tissue.

    Conclusions:

    • The lungs play a significant role in peptide metabolism, involving both normal physiological processes and pathological conditions.
    • Ectopic peptide hormone secretion by lung tumors can be a marker for disease and may lead to distinct clinical manifestations.
    • Understanding lung peptide metabolism is vital for diagnosing and managing various pulmonary and endocrine-related disorders.