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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
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Published on: May 2, 2013

beta 2-Microglobulin and transplantation antigens

L Trägårdh, O Kämpe, U Hammerling

    Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
    |January 1, 1980
    PubMed

    The complete amino acid sequence of papain-solubilized HLA A, B and C antigens representing the cell surface-expressed portion of the transplantation antigens has been elucidated. The HLA antigen heavy chains seem to be composed of three domains, one of which binds beta 2-microglobulin. The HLA antigen heavy chain domain closest to the membrane displays striking amino acid homology with immunoglobulin light and heavy chains and with beta 2-microglobulin. The other two domains, which show no statistically significant homology with immunoglobulins, are related to each other. This suggest that the HLA antigen heavy chains have arisen by a series of gene duplication events.

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