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Related Experiment Videos

Calcosis in generalized scleroderma.

A O Nielsen, B Brun, L Secher

    Acta Dermato-Venereologica
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This study reviewed 20 generalized scleroderma cases with calcinosis (Thibierge-Weissenbach syndrome). Esophageal and pulmonary issues were common, with novel findings of intervertebral calcifications in some patients.

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    Area of Science:

    • Rheumatology
    • Radiology
    • Gastroenterology

    Background:

    • Generalized scleroderma is a chronic connective tissue disease.
    • Calcinosis, or Thibierge-Weissenbach syndrome, is a recognized complication.
    • Clinical and radiological manifestations require further characterization.

    Purpose of the Study:

    • To review clinical and radiological findings in generalized scleroderma with calcinosis.
    • To identify common gastrointestinal and pulmonary manifestations.
    • To report novel observations, specifically intervertebral calcifications.

    Main Methods:

    • Retrospective review of 20 cases of generalized scleroderma with calcinosis.
    • Analysis of clinical symptoms and radiological findings.
    • Correlation of findings with existing literature.

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    Main Results:

    • Esophageal dysfunction reported in 60% of patients; radiological abnormalities in 85%.
    • Gastrointestinal complaints were consistent with previous reports.
    • Pulmonary function was frequently decreased, but pulmonary fibrosis was less common on chest X-ray.
    • Intervertebral calcifications in the thoracic and/or lumbar spine were observed in six patients.

    Conclusions:

    • Esophageal and gastrointestinal involvement is frequent in scleroderma with calcinosis.
    • Pulmonary involvement is common, but radiological evidence may not always correlate with functional impairment.
    • Intervertebral calcifications represent a potentially new radiological finding in this patient cohort.