Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Ultrastructural findings in the so-called minimal glomerular changes].

J Bucek, B Simcíková, L Küstková

    Ceskoslovenska Patologie
    |August 1, 1977
    PubMed
    Summary

    Ultrastructural evaluation of minimal glomerular lesions reveals frequent epithelial and endothelial cell changes, alongside significant mesangial matrix expansion and basement membrane thickening. These findings refine the understanding of kidney disease at a microscopic level.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Surgical treatment and management of cutaneous squamous cell carcinoma in patients with dystrophic epidermolysis bullosa - a case report.

    Acta chirurgiae plasticae·2022
    Same author

    Practical management of epidermolysis bullosa: consensus clinical position statement from the European Reference Network for Rare Skin Diseases.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2021
    Same author

    [Vascular dialysis access with transposed superficial femoral vein].

    Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2016
    Same author

    Ten years of DNA diagnostics of epidermolysis bullosa in the Czech Republic.

    The British journal of dermatology·2015
    Same author

    Autosomal recessive congenital ichthyoses in the Czech Republic.

    The British journal of dermatology·2015
    Same author

    Mycotic Aneurysm in the Aortoiliac Area - Current Options for Treatment.

    Zentralblatt fur Chirurgie·2013

    Area of Science:

    • Nephrology
    • Pathology
    • Electron Microscopy

    Context:

    • Minimal glomerular lesions (MGLs) are diagnosed via light microscopy.
    • Ultrastructural analysis offers deeper insights into cellular and matrix changes in MGLs.
    • This study focuses on pediatric and young adult kidney biopsies.

    Purpose:

    • To ultrastructurally characterize kidney biopsies diagnosed with minimal glomerular lesions.
    • To identify specific ultrastructural abnormalities in glomerular epithelia, endothelia, and mesangium.
    • To correlate light microscopic findings with detailed ultrastructural pathology.

    Summary:

    • Ultrastructural examination of 58 kidney biopsies with MGLs revealed frequent glomerular epithelial cell vacuolation/swelling (72.8%) and endothelial cell changes (46.6%).

    Related Experiment Videos

  • Mesangial alterations, including matrix expansion (44.8%) and scarring (13.6%), were prominent.
  • Focal basement membrane thickening (32.3%) was common, while deposits were rare (12.1%).

    • Impact:

    • Provides detailed ultrastructural pathology for minimal glomerular lesions.
    • Highlights the significance of mesangial and epithelial changes in MGLs.
    • Enhances diagnostic criteria and understanding of early-stage kidney pathology.