[Stimulation of antibody formation in mice by endogenous and exogenous interferon]

The effect of 2 types of interferon, virus-induced and endotoxin-induced, on the dynamics of antibody production in the immunization of mice with sheep red blood cells (SRBC) or E. coli vaccine was studied. Both types of interferon stimulated the production of antibodies against SRBC and, less effectively, against E. coli. This effect was found to depend on the dose of interferon (in a limited range). The immunostimulating titer of sera was comparable with their antivirus titer. These 2 types of interferon stimulated both primary and secondary response of mice to the injection of SRBC.