[Immunoprevention and immunotherapy of diseases caused by Gram-negative bacteria]

In recent years many researchers took interest in developing immunopreparations against diseases caused by opportunistic Gram-negative bacteria. The difficulties connected with the control of Gram-negative infections lie in the fact that most of the Gram-negative bacterial strains proved resistant to many antibiotics used in medicine. The development of immunopreparations should be based on the correct choice of the vaccine strain, as well as on the indications for the use of these preparations and the sphere of their application. The development of the above immunopreparations should be apparently based on the principle of obtaining soluble purified protective antigens, constituting homologous and, possibly, heterologous serum preparations with a specific effect.