[Effect of polyanions on macrophage-lymphocyte interaction]

The effect of polyanions on the interaction of antigen-stimulated macrophages and lymphocytes was studied in vivo. Treatment of cell mixture of macrophages and lymphocytes with poly = A : U or dextran sulfate induced a considerable increase in the number of lymphocytes contacting with macrophages during the first hours of cultivation. Under similar conditions yeast RNA had a certain anticooperative effect. According to the data obtained by scanning electron microscopy, the contacts between the interacting cells were realized by means of cytoplasmic bridges or close membrane connections.