Effect of beta-blocking drugs on peripheral blood flow in intermittent claudication

To determine the possible effects of beta-adrenergic blocking drugs on blood flow in arteriosclerotic peripheral vascular disease, we have measured muscle blood flow in eight patients with intermittent claudication who were taking beta-blocking drugs for mild uncomplicated hypertension. Patients completed daily, pindolol 5 mg three times daily, atenolol 100 mg daily, or placebo. Mean exercise muscle blood flow fell by approximately 30% after each active drug when compared to placebo. beta-Blocking drugs may be contraindicated in the presence of peripheral vascular disease. Cardioselectivity and partial agonist activity appear to confer no advantages in such patients.