Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyamines in the developing mouse brain.

T W Jasper, W G Luttge, T B Benton

    Developmental Neuroscience
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The role of gonadal hormones in the sexual behavior of the rhesus monkey and human: A literature survey.

    Archives of sexual behavior·2013
    Same author

    Characterization of Glucocorticoid Type II Receptors in Neuronal and Glial Cultures from Rat Brain.

    Journal of neuroendocrinology·2009
    Same author

    Placenta and growth factors in fetal growth and nutrition.

    Nutrition (Burbank, Los Angeles County, Calif.)·1997
    Same author

    The role of the placenta in fetal nutrition and growth.

    Journal of the American College of Nutrition·1996
    Same author

    H-2 gene complex and corticosteroid responsiveness: evidence that the corticosteroid hormone signal transduction pathway in the adult mouse lung is not associated with haplotype-specific responses to corticosteroids.

    Steroids·1993
    Same author

    Expression of mineralocorticoid type I and glucocorticoid type II receptors in astrocyte glia as a function of time in culture.

    Brain research. Developmental brain research·1991
    Same journal

    Microbiota-Based Interventions Differentially Rescue Gut and Social Behavior Phenotypes in Drosophila with Kdm5 Deficiency.

    Developmental neuroscience·2026
    Same journal

    Maternal Infection Induces Neuronal Structure and Behavioural Alterations in Experimental Meningitis Rat Model.

    Developmental neuroscience·2026
    Same journal

    Development of the Gut Microbiota throughout the First Year of Life and Its Association with Socio-Emotional Development into Childhood.

    Developmental neuroscience·2026
    Same journal

    Intranasal Inhibition of Tropomyosin Receptor Kinase B Signaling during Early Postnatal Development Disrupts Growth and Sensorimotor Maturation in Neonatal Rodents.

    Developmental neuroscience·2026
    Same journal

    Long-Term Consequences of Preterm Birth: A Lifespan Perspective.

    Developmental neuroscience·2026
    Same journal

    From Womb to Weaning: Microbial Signals That Shape the Developing Brain.

    Developmental neuroscience·2026
    See all related articles

    During mouse brain development, polyamine levels rise with neurogenesis and cell growth, then decline. Polyamines per cell decrease during neurogenesis, with spermidine linked to myelin in the brainstem.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Biochemistry

    Background:

    • Polyamines are crucial for cell growth and proliferation.
    • Their specific roles in normal brain development require further elucidation.
    • Understanding polyamine dynamics is key to comprehending neural development.

    Purpose of the Study:

    • To investigate the developmental trajectory of polyamine levels in the male and female mouse brain.
    • To correlate polyamine fluctuations with key developmental processes like neurogenesis and cell packing.
    • To explore potential sex-specific differences in polyamine metabolism during brain development.

    Main Methods:

    • Quantification of tissue polyamine levels across various brain regions (cerebral cortex, cerebellum, hypothalamus, rhombencephalon-midbrain) during pre- and postnatal development.

    Related Experiment Videos

  • Assessment of cell packing density using DNA levels as a proxy.
  • Analysis of polyamine concentrations on a per-cell basis.

    • Main Results:

    • Tissue polyamine levels increased in all brain regions during periods of high neurogenesis and cell proliferation.
    • Polyamine levels subsequently decreased in a tissue-specific manner towards adult levels.
    • Polyamine concentrations per cell decreased during neurogenesis, while rhombencephalon-midbrain spermidine increased later, suggesting a role in myelination.
    • No significant sex differences were observed in polyamine levels or developmental patterns.

    Conclusions:

    • Polyamine levels dynamically change during mouse brain development, correlating with neurogenesis and cell density.
    • The observed patterns suggest distinct roles for polyamines in different developmental stages and brain regions.
    • Spermidine's late increase in the brainstem supports its association with myelin formation.
    • The absence of sex differences indicates conserved polyamine roles in male and female mouse brain development.