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Angiogenesis: initiation and control.

J Folkman

    Annals of the New York Academy of Sciences
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Capillary growth, or angiogenesis, involves cell migration and tube formation. Mast cells, using heparin, appear to aid this process by preparing the matrix for endothelial cell movement.

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    Area of Science:

    • Vascular Biology
    • Cellular Physiology

    Background:

    • Capillary growth (angiogenesis) is a complex process.
    • Angiogenic stimuli originate from tumors and non-neoplastic cells like macrophages, lymphocytes, and adipocytes.

    Purpose of the Study:

    • To elucidate the ordered sequence of events in capillary growth.
    • To understand the role of different cell types and factors in angiogenesis.

    Main Methods:

    • In vivo experiments using rabbit cornea models.
    • In vitro studies involving cloned capillary endothelial cells in long-term culture.

    Main Results:

    • Capillary growth involves basement membrane lysis, endothelial cell migration, lumen formation, branching, and anastomosis.
    • Mast cells, via heparin, may facilitate endothelial cell migration by matrix preparation.

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    Conclusions:

    • Combined in vitro and in vivo methods enhance understanding of capillary growth initiation and control.
    • Mast cells act as helper cells in angiogenesis, with heparin as a key factor.