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Related Experiment Videos

Is oncogene addiction angiogenesis-dependent?

J Folkman1, S Ryeom

  • 1The Vascular Biology Program, Department of Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

Cold Spring Harbor Symposia on Quantitative Biology
|July 28, 2006
PubMed
Summary
This summary is machine-generated.

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Cancer cells require continued oncogene activation for growth, a process termed oncogene addiction. This addiction is dependent on tumor angiogenesis, the formation of new blood vessels, for sustained tumor expansion.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Activated oncogenes initiate tumor growth but their sustained requirement for maintaining the cancer phenotype is debated.
  • Tumor growth beyond microscopic size requires mechanisms beyond increased proliferation and decreased apoptosis.

Purpose of the Study:

  • To investigate the role of angiogenesis in oncogene addiction.
  • To test the hypothesis that oncogene addiction is angiogenesis-dependent.

Main Methods:

  • Experiments involving doxycycline-regulated oncogene activation and inactivation in tumor models.
  • Analysis of tumor growth, proliferation, apoptosis, and angiogenesis.

Main Results:

  • Activated oncogenes induce tumor growth that regresses upon inactivation (oncogene addiction).

Related Experiment Videos

  • Oncogene activation alone is insufficient for tumor mass expansion beyond microscopic size.
  • Tumor mass expansion requires oncogenes to induce tumor angiogenesis.

    • Conclusions:

    • Oncogene addiction is critically dependent on tumor angiogenesis.
    • The "endothelial centric" hypothesis of oncogene addiction warrants further investigation.