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Prolactin and prostate: a chronobiologic study.

C Selli, M Benvenuti, F Melone

    European Urology
    |January 1, 1983
    PubMed
    Summary
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    Serum prolactin levels appear impaired in patients with benign prostatic hypertrophy and prostatic carcinoma. Chronobiological investigation is crucial, as single samples can be misleading without temporal reference standards.

    Area of Science:

    • Endocrinology
    • Urology
    • Chronobiology

    Background:

    • Prolactin's role in prostatic diseases remains unclear, with existing studies yielding misleading results.
    • Serum prolactin levels are significantly influenced by temporal variations, particularly circadian rhythms.

    Purpose of the Study:

    • To investigate the chronobiological patterns of serum prolactin in patients with benign prostatic hypertrophy (BPH) and prostatic carcinoma.
    • To determine if temporal variations in prolactin levels are altered in these prostatic conditions.

    Main Methods:

    • Chronobiological investigation of serum prolactin levels.
    • Analysis of prolactin levels in 12 patients with BPH and 7 patients with prostatic carcinoma.

    Main Results:

    Related Experiment Videos

    • An impairment in serum prolactin levels was observed in patients with both BPH and prostatic carcinoma.
    • These findings highlight the importance of temporal profiling of prolactin.

    Conclusions:

    • Serum prolactin levels show chronobiological alterations in benign prostatic hypertrophy and prostatic carcinoma.
    • Single serum prolactin measurements may be insufficient and potentially misleading without considering temporal variations and established chronodesms.