Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Salivary secretion induced by substance P.

J H Yu, S M Burns, C A Schneyer

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |September 1, 1983
    PubMed
    Summary

    Substance P (SP) stimulates salivary secretion in rats, acting through both cholinergic and specific SP receptors. This research clarifies the mechanisms behind SP-induced fluid, ion, and amylase release from salivary glands.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Expert consensus on nonsurgical endodontic retreatment].

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2025
    Same author

    [Epidemic Characteristics and disease burden trend of cervical cancer in Guangxi Zhuang Autonomous Region, 2010-2017].

    Zhonghua zhong liu za zhi [Chinese journal of oncology]·2025
    Same author

    [A case of cardiac valvular dysplasia combined with dilated cardiomyopathy caused by a homozygous nonsense variant in PLD1].

    Zhonghua xin xue guan bing za zhi·2024
    Same author

    Physiological and behavioural adaptations by big brown bats hibernating in dry rock crevices.

    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·2024
    Same author

    [Research status of potential therapeutic targets for thyroid-associated ophthalmopathy].

    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2024
    Same author

    [Research progress on the epidemiology and risk factors of dry eye in children].

    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2023

    Area of Science:

    • Physiology
    • Pharmacology
    • Gastroenterology

    Background:

    • Substance P (SP) is a neuropeptide known to influence various physiological processes.
    • Its role in salivary gland secretion, particularly the mechanisms involved, requires further elucidation.

    Purpose of the Study:

    • To investigate the effects of intravenous substance P (SP) on salivary secretion in rats.
    • To determine the involvement of cholinergic pathways and specific receptors in SP-mediated salivary gland responses.

    Main Methods:

    • Intravenous injection of substance P (SP) in rats.
    • Collection and analysis of saliva from parotid and submaxillary glands.
    • Assessment of the effects of atropine on SP-induced salivary secretion and composition.

    Related Experiment Videos

    Main Results:

    • Substance P (SP) induced significant secretion of fluid, ions, and amylase from rat parotid and submaxillary glands.
    • SP-evoked salivary flow was blocked by atropine, indicating a cholinergic component.
    • Atropine did not alter the composition of SP-evoked saliva, suggesting additional specific SP receptor involvement.

    Conclusions:

    • Salivary secretion induced by substance P (SP) is mediated by SP-sensitive cholinergic receptors.
    • The secretion of ions and amylase evoked by SP involves specific SP receptors, distinct from the cholinergic pathway for fluid flow.