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Summary
Several antiviral drugs are effective for various viral infections. Trifluridine, idoxuridine, vidarabine, and acyclovir treat herpes simplex virus and herpes zoster. Amantadine and rimantadine combat influenza A.
Area of Science:
- Virology
- Pharmacology
- Infectious Diseases
Background:
- Antiviral therapies are crucial for managing viral infections.
- Several antiviral compounds are currently available, with others under investigation.
Purpose of the Study:
- To review the efficacy of available antiviral compounds.
- To highlight antiviral agents of significant interest for various viral infections.
Main Methods:
- Literature review of antiviral drug efficacy.
- Summary of clinical applications for specific antiviral agents.
Main Results:
- Topical trifluridine, idoxuridine, and vidarabine are effective for herpes simplex virus keratoconjunctivitis.
- Vidarabine and acyclovir show efficacy in herpes simplex virus encephalitis and herpes zoster in immunocompromised patients.
- Acyclovir is effective for primary and recurrent herpes genitalis via multiple administration routes.
- Amantadine and rimantadine are effective for influenza A prophylaxis and treatment.
- Ribavirin and interferon show potential for respiratory syncytial virus and common cold treatment, respectively.
Conclusions:
- Established antiviral drugs like acyclovir and vidarabine are vital for treating herpes infections.
- Amantadine and rimantadine are key for influenza A management.
- Emerging antivirals such as ribavirin and interferon warrant further investigation for broader applications.