Serum acid phosphatase elevation associated with transurethral resection syndromes

Area of Science:

• Urology
• Biochemistry

Background:

• Benign prostatic hyperplasia (BPH) is a common condition in aging men.
• Transurethral resection of the prostate (TURP) is a standard surgical treatment for symptomatic BPH.
• Post-transurethral prostate resection syndrome (P-TURPS) is a recognized complication following the procedure.

Observation:

• Six patients undergoing TURP for BPH developed P-TURPS.
• Preoperative serum acid phosphatase levels were normal in all patients.
• Postoperative serum acid phosphatase levels were elevated in the recovery room, returning to normal by the first postoperative day.

Findings:

• Elevated serum acid phosphatase levels indicate significant intraoperative absorption of prostate tissue substances.
• The observed enzyme elevations correlate with the development of P-TURPS symptoms.
• This suggests a biochemical basis for the syndrome.

Implications:

• The findings suggest that P-TURPS may result from the intravenous absorption of prostate tissue substances, in addition to irrigant solutions.
• Understanding this mechanism can lead to improved patient monitoring and potentially new preventative strategies.
• Further research is warranted to elucidate the exact pathways and clinical significance of prostate tissue absorption during TURP.