Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathogenesis of erythromelalgia.

H P Jorgensen, J Sondergaard

    Archives of Dermatology
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Patients with erythromelalgia show defective prostaglandin metabolism, leading to abnormal skin reactions and increased prostaglandin levels. Aspirin may help by influencing this metabolism.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A pilot study of mercury in Greenland sled dogs in Greenland: Civilian versus military owned dogs. Greenlandic: Mississueqqaarneq Qimmit Qimuttut Aavani Meqquinilu Kviksiilveqarnersut.

    Environmental research·2025
    Same author

    Highly dynamic gamma-ray emissions are common in tropical thunderclouds.

    Nature·2024
    Same author

    Flickering gamma-ray flashes, the missing link between gamma glows and TGFs.

    Nature·2024
    Same author

    The effects of diabetes clubs on peer-support, disclosure of diabetes status, and sources of information regarding diabetes management: results of a pilot-intervention in rural Vietnam.

    Public health·2024
    Same author

    GPs' prescription patterns, experience, and attitudes towards medicinal cannabis-a nationwide survey at the early stage of the Danish test scheme.

    BMC primary care·2023
    Same author

    Chronic opioid use before and after exercise therapy and patient education among patients with knee or hip osteoarthritis.

    Osteoarthritis and cartilage·2022
    Same journal

    Scoring With SCORTEN-Reply.

    Archives of dermatology·2017
    Same journal

    Comparison of Early and Late Latent Syphilis- Colorado, 1991.

    Archives of dermatology·2016
    Same journal

    Case of Rhinoscleroma.

    Archives of dermatology·2016
    Same journal

    Cutaneous Fungal Infections.

    Archives of dermatology·2016
    Same journal

    An Ulcerated Plaque in a Gay Man.

    Archives of dermatology·2016
    Same journal

    Solitary Violaceous Nodule on the Face.

    Archives of dermatology·2016
    See all related articles

    Area of Science:

    • Biochemistry
    • Dermatology
    • Pharmacology

    Background:

    • Erythromelalgia is a condition characterized by skin redness and burning sensations.
    • Prostaglandins are lipid compounds with diverse hormone-like effects in humans.

    Observation:

    • Two erythromelalgia patients exhibited abnormal skin reactions to prostaglandins (PGE1, PGE2, PGF1alpha) but normal reactions to histamine, serotonin, and bradykinin.
    • Elevated levels of prostaglandin-like material were found in skin perfusates of these patients.
    • Increased prostaglandin synthesis capacity was observed in skin biopsies from the patients.

    Findings:

    • Defective prostaglandin metabolism is implicated in erythromelalgia.
    • Skin perfusates from patients showed significantly higher prostaglandin concentrations (2.0-3.2 ng/ml) compared to controls (0.1 ng/ml).

    Related Experiment Videos

  • Skin biopsy samples indicated an enhanced capacity for prostaglandin synthesis.

    • Implications:

    • Understanding prostaglandin metabolism defects may explain erythromelalgia's clinical features.
    • Aspirin's therapeutic effect in erythromelalgia might stem from its influence on prostaglandin metabolism.
    • Further research into prostaglandin pathways could reveal new therapeutic targets for erythromelalgia.