[RNA biosynthesis in various organs of the rat in experimental peritonitis]

Synthesis of various RNA species was studied in liver, spleen, and kidney tissues of one year old Wistar rat males within 6, 12, 24 and 48 hrs after peritonitis development. RNA biosynthesis was found to be unaltered in kidney; in liver tissue it was distinctly decreased beginning from 24 hrs and lowered down to 40% of the control value within 2 days. In spleen an increase in synthesis of pro-mRNA (90%) and mRNA was observed at early steps of peritonitis, with the subsequent decrease of these patterns within 24-48 hrs as compared with the previous periods of the disease as well as with controls. The most pronounced inhibition of RNA synthesis (pro-mRNA, mRNA) coincided in time with death of the animals.