[Testosterone regulation of hexokinase and phosphofructokinase activity in androgen-sensitive tissues]

Possible regulatory effect of testosterone on hexokinase and phosphofructokinase activities was studied in rats seminal vesicles and prostatic gland. cAMP, but not cGMP, was shown to stimulate the testosterone induction of these enzymes in androgen-sensitive tissues. Cooperative increase in efficiency, observed after simultaneous administration of testosterone and inhibitors of phosphodiesterase, suggested the possible mechanism of cyclonucleotide-mediated regulation of enzymes by androgens. Regulation of the glycolysis kev enzymes appears to be carried out via two mechanisms; binding with androgen receptors of cytosol and an increase of intracellular cAMP concentration apparently by means of phosphodiesterase inhibition.