[Lymphomatoid papulosis. Review and personal observation of 4 patients]

121 patients with lymphomatoid papulosis from the literature are reviewed with respect to clinical and histological features, laboratory findings, therapy and course of the disease. In addition, clinical, histological, enzymecytochemical and immunological findings in four own patients with lymphomatoid papulosis are reported. Males are more often affected than females. The typical clinical features are papules measuring 1-2 cm in diameter, most frequently located at the extremities. The course of the disease is rhythmic prolonged over many years. Transition into malignant lymphoma occurs. The presence of blasts and epidermotropism of the infiltrate are obligatory histological criteria. Mitoses are present in about two thirds of the patients. Signs of vasculitis, eosinophilic and neutrophilic granulocytes are found in less than half of the patients. Based on enzyme cytochemical and immunocytological findings in conjunction with the course of the disease lymphomatoid papulosis is designated as pseudolymphoma of T-cell type.