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[Allergy to preservatives].

J M Meynadier, J Meynadier, A Colmas

    Annales De Dermatologie Et De Venereologie
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    This study identified common cosmetic and drug preservatives causing allergic dermatitis in 465 patients. Formaldehyde and Bronopol showed high sensitization rates, suggesting a need to reduce their use in products.

    Area of Science:

    • Dermatology
    • Allergology
    • Cosmetic Science

    Context:

    • Investigates allergic contact dermatitis in patients exposed to cosmetics, drugs, industrial products, and clothing.
    • Utilizes patch testing with 29 common and sensitizing preservatives.
    • Involves multi-center data collection across seven French dermatology clinics over one year.

    Purpose:

    • To identify the prevalence of preservative allergies in patients with suspected contact dermatitis.
    • To evaluate the sensitizing potential of frequently used and highly allergenic preservatives.
    • To provide data guiding the reduction of specific preservative use due to high incidence of sensitivity.

    Summary:

    • Tested 465 patients aged 2-80 with 29 preservatives.
    • High positive reaction rates observed for formaldehyde (4.7%), Bronopol (4.7%), and ammoniated mercury chloride (3.8%).

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  • Other identified allergens include benzoic acid, sodium benzoate, parabens, dichlorophen, chloracetamid, and benzyl benzoate.

    • Impact:

    • Highlights the significant allergenic potential of formaldehyde, Bronopol, and ammoniated mercury chloride, recommending decreased usage.
    • Identifies chloracetamid as a highly sensitizing agent despite potentially low usage frequency.
    • Suggests that while parabens are widely used, positive reactions are rare and often linked to topical medications.