Nevus lipomatosus cutaneus superficialis. A light and electron microscopic study

Area of Science:

• Dermatology
• Pathology
• Histology

Background:

• Nevus lipomatosus cutaneus superficialis (NLCS) is a rare idiopathic condition characterized by dermal adipose tissue.
• Lesions typically present congenitally or by the third decade, predominantly in the pelvic-girdle region.

Observation:

• A unique case of NLCS is presented, with lesions arising in the fifth decade of life.
• The affected area was unusually confined to the abdominal wall, differing from typical presentations.

Findings:

• Histopathology revealed mature adipose tissue, perivascular mononuclear cell infiltrates, and abundant mast cells.
• Electron microscopy showed mature lipocytes within perivascular infiltrates, but no lipoblasts or mesenchymal cell transitions were observed.

Implications:

• This case expands the known clinical and temporal presentation spectrum of Nevus lipomatosus cutaneus superficialis.
• Further research may elucidate the specific cellular mechanisms and triggers for late-onset NLCS, particularly in atypical locations.