[Changes of neuronal activity in the rat's hippocampus under long-term treatment with desipramine]

Long-term treatment of rats with the antidepressive desipramine increase in the hippocampus the number of neurons with low spontaneous discharges and affects the animals' response to microiontophoretically applied noradrenalin. Additional acute administration of desipramine causes, after long-term treatment with the antidepressive, a stronger increase in noradrenalin induced inhibition of the firing rates as compared with controls.