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Related Experiment Videos

Circulating catecholamines in exercise and hyperventilation induced asthma.

P J Barnes, M J Brown, M Silverman

    Thorax
    |June 1, 1981
    PubMed
    Summary

    Asthmatic patients show a reduced sympatho-adrenal response during exercise, with lower increases in noradrenaline and adrenaline. This may contribute to exercise-induced bronchospasm by affecting mast cell activity.

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    Area of Science:

    • Pulmonary Medicine
    • Exercise Physiology
    • Biochemistry

    Background:

    • Exercise-induced bronchospasm (EIB) is a common condition in asthmatics.
    • The physiological mechanisms underlying EIB, particularly the role of the sympatho-adrenal system, are not fully understood.

    Purpose of the Study:

    • To investigate the plasma catecholamine (noradrenaline and adrenaline) and cyclic AMP (cAMP) responses to exercise in asthmatic patients with EIB.
    • To compare these responses with those of healthy individuals.
    • To explore the role of catecholamines in EIB by comparing exercise and isocapnic hyperventilation challenges.

    Main Methods:

    • Measured plasma noradrenaline, adrenaline, and cAMP levels in seven asthmatic patients and six healthy controls.
    • Subjects underwent a standard treadmill exercise test and matched isocapnic hyperventilation.

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  • Assessed bronchoconstriction by measuring the fall in peak expiratory flow rate.

    • Main Results:

    • Normal subjects exhibited significant increases in noradrenaline (5.5-fold) and adrenaline (3.2-fold) during exercise.
    • Asthmatics showed a blunted response with a smaller noradrenaline rise (2.1-fold) and no significant adrenaline increase, alongside significant bronchoconstriction (28.4% fall in peak flow).
    • Plasma cAMP rose in controls but not in asthmatics; hyperventilation induced bronchospasm in asthmatics without altering catecholamines.

    Conclusions:

    • Asthmatics with EIB demonstrate a reduced sympatho-adrenal response to exercise.
    • This diminished catecholamine response may facilitate bronchoconstriction by impacting mast cell-mediated inflammatory pathways.
    • Circulating catecholamines appear to play a permissive, rather than direct, role in EIB, potentially through mast cell interactions.