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Adrenal function in women with idiopathic acne
The Journal of Investigative Dermatology
|June 1, 1982
Summary
Adrenal androgen levels in women with acne were only mildly elevated compared to controls, suggesting they are not the sole cause of this common skin condition.
Area of Science:
- Endocrinology
- Dermatology
- Reproductive Health
Background:
- Idiopathic acne affects many postadolescent women.
- The role of adrenal androgens in acne pathogenesis is debated.
Purpose of the Study:
- To investigate adrenal androgen secretion in women with idiopathic acne.
- To compare hormone levels in acne patients versus healthy controls.
Main Methods:
- Radioimmunoassay measurement of plasma androgens (DHA, DHAS, androstenedione, testosterone) and related steroids (cortisol, 17-hydroxyprogesterone, 11-deoxycortisol).
- Analysis in basal state and during 48-hour ACTH infusion in 9 women with acne and age/sex-matched controls.
Main Results:
- Adrenal androgens were 15-25% higher in acne patients, but not significantly different (p > .05).
- Plasma testosterone levels were similar between groups.
- Cortisol and related steroid responses to ACTH were comparable in both groups.
Conclusions:
- Adrenal androgen secretion is only mildly elevated in idiopathic acne and unlikely to be the sole cause.
- Sebaceous gland sensitivity or local skin metabolism of androgens may play a role in acne development.