Technique for microwave-induced hyperthermia in superficial human tumours

Area of Science:

• Medical Physics
• Oncology
• Biomedical Engineering

Background:

• Local hyperthermia is a promising treatment for superficial tumors.
• Effective temperature control is crucial for hyperthermia efficacy and safety.
• Microwave applicators offer potential for targeted heating.

Purpose of the Study:

• To develop and evaluate a computer-controlled microwave hyperthermia system for superficial tumors.
• To investigate the feasibility of invasive temperature monitoring for precise thermal control.
• To assess the accuracy and stability of the system's temperature regulation.

Main Methods:

• Construction of a 2,450 MHz microwave generator with a direct contact applicator.
• Invasive temperature monitoring using small thermistor probes (0.6 mm diameter).
• Implementation of an automatic control system with pulsed irradiation and a master thermistor for feedback.

Main Results:

• The system enabled precise temperature control within +/- 0.5°C of the preset value at the master thermistor.
• Pulsed irradiation effectively mitigated electromagnetic interference with metallic temperature probes.
• Simultaneous monitoring of up to eight thermistors allowed for comprehensive thermal assessment.

Conclusions:

• The developed computer system provides accurate and stable temperature control for microwave hyperthermia in superficial tumors.
• Invasive thermistor-based feedback and pulsed irradiation are effective strategies for precise thermal management.
• This technology holds potential for improving the clinical application of hyperthermia in cancer treatment.