Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Marijuana: interaction with the estrogen receptor.

M A Sauer, S M Rifka, R L Hawks

    The Journal of Pharmacology and Experimental Therapeutics
    |February 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The relation of relative hormonal levels and physical development and social-emotional behavior in young adolescents.

    Journal of youth and adolescence·2013
    Same author

    Resistance to multiple steroids in two sisters.

    The Journal of steroid biochemistry and molecular biology·2001
    Same author

    Cortisol production rates in subjects with suspected Cushing's syndrome: assessment by stable isotope dilution methodology and comparison to other diagnostic methods.

    The Journal of clinical endocrinology and metabolism·2000
    Same author

    Resistance to several steroids in two sisters.

    The Journal of clinical endocrinology and metabolism·1999
    Same author

    Cortisol production rate measurement by stable isotope dilution using gas chromatography-negative ion chemical ionization mass spectrometry.

    Steroids·1999
    Same author

    Cavernous sinus sampling is highly accurate in distinguishing Cushing's disease from the ectopic adrenocorticotropin syndrome and in predicting intrapituitary tumor location.

    The Journal of clinical endocrinology and metabolism·1999
    Same journal

    Striatal remodeling in Parkinson disease.

    The Journal of pharmacology and experimental therapeutics·2026
    Same journal

    Loaded and coated: Outer membrane vesicles get a critical boost from a lipopolysaccharide adjuvant payload in a rationally designed anti-Helicobacter pylori nanoparticle.

    The Journal of pharmacology and experimental therapeutics·2026
    Same journal

    Comparative analysis of ligand binding affinities and functional profiles at recombinant human β-adrenergic receptor subtypes 1, 2, and 3.

    The Journal of pharmacology and experimental therapeutics·2026
    Same journal

    Decoding the oncogenic functions and translational potential of Twinfilin-1.

    The Journal of pharmacology and experimental therapeutics·2026
    Same journal

    Antiproliferative effects of HIV integrase strand transfer inhibitors in experimental models for cancer research: A narrative review.

    The Journal of pharmacology and experimental therapeutics·2026
    Same journal

    Modulation of morphine tolerance and dependence by pyrroloquinoline quinone in mice: Insights into mechanistic bridge from N-methyl-D-aspartate receptors-calcium/calmodulin-dependent protein kinase II signaling to oxidative neuroinflammation.

    The Journal of pharmacology and experimental therapeutics·2026
    See all related articles

    Marijuana extract and smoke components bind to estrogen receptors, but cannabis does not show direct estrogenic activity in vivo. Further research is needed to understand these interactions.

    Area of Science:

    • Endocrinology
    • Pharmacology
    • Phytochemistry

    Background:

    • Cannabis contains compounds that may interact with the endocrine system.
    • Estrogen receptors play a crucial role in various physiological processes.

    Purpose of the Study:

    • To investigate the interaction of cannabis components with estrogen receptors.
    • To determine the in vivo estrogenic or antiestrogenic activity of cannabis extract.

    Main Methods:

    • In vitro receptor binding assays using rat uterine cytosol.
    • In vivo uterine growth bioassay in immature rats.

    Main Results:

    • Crude marijuana extract and smoke condensate competed with estradiol for estrogen receptor binding.

    Related Experiment Videos

  • Cannabidiol showed weak estrogen receptor binding at high concentrations.
  • Apigenin, a cannabis flavonoid, displayed high estrogen receptor affinity.
  • Cannabis extract did not exhibit estrogenic or antiestrogenic effects in the uterine growth bioassay.

    • Conclusions:

    • While some cannabis components bind to estrogen receptors, cannabis extract lacks direct estrogenic activity in vivo.
    • The biological significance of observed in vitro receptor binding requires further investigation.