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Related Experiment Videos

Intramammary lymph nodes.

R L Egan, M B McSweeney

    Cancer
    |May 15, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Intramammary lymph nodes are present in 28% of operable breast cancers, with 10% showing metastasis. These nodes impact prognosis, especially in early-stage disease, suggesting a potential new staging classification.

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    Area of Science:

    • Oncology
    • Pathology
    • Radiology

    Background:

    • Intramammary lymph nodes (IMLNs) are a potential site for breast cancer metastasis.
    • Their prevalence and impact on prognosis require further investigation.

    Purpose of the Study:

    • To investigate the incidence and significance of intramammary lymph nodes in primary operable breast carcinoma.
    • To determine the relationship between IMLNs and breast cancer staging and prognosis.

    Main Methods:

    • Radiographic, gross, and histopathologic examination of 158 whole breasts with primary operable carcinoma.
    • Analysis of the location and metastatic status of identified intramammary lymph nodes.

    Main Results:

    • Intramammary lymph nodes were identified in 28% of cases, with 10% containing metastatic carcinoma.

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  • Metastatic IMLNs were found in all breast quadrants, not always correlating with the primary tumor location or typical lymphatic drainage.
  • Positive IMLNs did not affect prognosis in Stage II carcinoma but indicated advanced disease and higher likelihood of axillary metastasis.
  • A trend toward poorer prognosis was observed in Stage I lesions with positive IMLNs.

    • Conclusions:

    • Intramammary lymph nodes can harbor metastatic breast cancer.
    • Positive IMLNs in Stage I disease may indicate a prognosis similar to Stage II disease.
    • The findings suggest a potential for a new staging classification (Stage Ia) for cases with positive IMLNs but negative axillary lymph nodes.