GABA binding in human blood platelets: in vitro effects of lithium and rubidium chlorides

Methodologic and kinetic properties of gamma-aminobutyric acid (GABA) binding were studied in platelet materials of different nature. Platelet GABA binding was saturable and specific. LiCl and RbCl added in vitro at concentration of 0.01 mM increased significantly platelet GABA binding. This activator effect, and its kinetic characteristics were different from those obtained for GABA uptake and 5-hydroxytryptamine (5-HT) binding, which suggest that the three processes are different in platelets.