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Intestinal perforation associated with cytomegalovirus infection in patients with acquired immune deficiency syndrome

D Frank, R F Raicht

    The American Journal of Gastroenterology
    |March 1, 1984
    PubMed

    Insights

    Gastrointestinal complications, including intestinal perforation, are serious in patients with acquired immune deficiency syndrome (AIDS). Cytomegalovirus infection may cause this severe bowel complication in individuals with AIDS.

    Area of Science:

    • Gastroenterology
    • Virology
    • Immunology

    Background:

    • Gastrointestinal complications are a significant concern in patients with acquired immune deficiency syndrome (AIDS).
    • Intestinal perforation is a rare but life-threatening complication.
    • Cytomegalovirus (CMV) is a common opportunistic infection in immunocompromised individuals.

    Observation:

    • This report details two cases of male homosexuals diagnosed with AIDS.
    • Both patients presented with severe gastrointestinal symptoms that progressed to intestinal perforation.
    • Distinct Cytomegalovirus (CMV) inclusions were observed at the sites of intestinal perforation.

    Findings:

    • The presence of CMV inclusions at perforation sites suggests a direct role of the virus.
    • CMV-induced enteritis is proposed as a potential mechanism leading to bowel perforation.
    • This highlights a specific gastrointestinal complication associated with CMV in AIDS patients.

    Implications:

    • Understanding the role of CMV in intestinal perforation is crucial for managing AIDS patients.
    • Early diagnosis and treatment of CMV enteritis may help prevent intestinal perforation.
    • This finding contributes to the knowledge of opportunistic infections and their severe consequences in immunocompromised individuals.

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