Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

From sea lemons to c-waves.

Cellular and Molecular Neurobiology

|December 1, 1983

Summary

This summary is machine-generated.

Retinal pigment epithelial (RPE) cells control the photoreceptor environment and eye

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Did Edgar Degas have Stargardt disease?

Ophthalmic genetics·2021

Same author

Vision, eye disease, and art: 2015 Keeler Lecture.

Eye (London, England)·2015

Same author

ISCEV Standard for full-field clinical electroretinography (2008 update).

Documenta ophthalmologica. Advances in ophthalmology·2008

Same author

[The influence of experimental scotoma on multifocal electroretinogram].

Yan ke xue bao = Eye science·2003

Same author

Pulsed electron avalanche knife (PEAK) for intraocular surgery.

Investigative ophthalmology & visual science·2001

Same author

Acute effects of sildenafil on the electroretinogram and multifocal electroretinogram.

American journal of ophthalmology·2001

Same journal

The Diagnostic and Therapeutic Value of Micro-RNA in Parkinson's Disease.

Cellular and molecular neurobiology·2026

Same journal

An Engineered Multifunctional Fusion Protein Targeting Aβ Oligomers, Microglia and Autophagy Ameliorates Cognitive Deficits and Amyloid Pathology in Alzheimer's Disease Mice.

Cellular and molecular neurobiology·2026

Same journal

Plasma Biomarkers for Alzheimer's Disease Across the Continuum: A Systematic Review of SIMOA-Based Studies.

Cellular and molecular neurobiology·2026

Same journal

Loss of miR-204 Drives NPTX1-Dependent Mitochondrial Dysfunction and Neuronal Degeneration in Alzheimer's Disease.

Cellular and molecular neurobiology·2026

Same journal

Prdm15 Deficiency Results in Impaired Hippocampal Neurogenesis and Autism-Like Behaviors.

Cellular and molecular neurobiology·2026

Same journal

Activation of the Reverse Cholesterol Transport Pathway: A Strategy to Ameliorate Lipid Metabolic Dyshomeostasis in the Microenvironment Following Spinal Cord Injury.

Cellular and molecular neurobiology·2026

See all related articles

Area of Science:

Cellular neurobiology
Retinal physiology
Ocular electrophysiology

Background:

The retinal pigment epithelium (RPE) is a vital epithelial layer.
It forms tight junctions, controlling the photoreceptor outer segment environment.
RPE possesses distinct apical and basal membrane electrical properties.

Purpose of the Study:

To review retinal pigment epithelial (RPE) physiology.
To illustrate the application of cellular neurophysiology principles to clinical questions.
To honor Anthony L. F. Gorman's contributions to neurobiology.

Main Methods:

Review of existing literature on RPE physiology.
Analysis of RPE's role in retinal adhesion and water transport.
Examination of RPE's contribution to the electroretinogram (ERG) c-wave and standing potential.

Related Experiment Videos

Main Results:

RPE adhesion is modulated by various chemical factors (cyanide, pH, calcium, ouabain, acetazolamide).
RPE water transport to the choroid is affected by hypoxia, cyanide, ouabain, and acetazolamide.
RPE membrane potentials contribute significantly to the eye's standing potential and ERG c-wave.

Conclusions:

Cellular neurophysiology principles are applicable to understanding RPE function.
RPE plays a critical role in maintaining retinal integrity and visual function.
Understanding RPE physiology has direct clinical relevance for eye diseases.