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[Intracoronary thrombolysis].

C Cernigliaro, M Sansa, A Campi

    Giornale Italiano Di Cardiologia
    |January 1, 1983
    PubMed
    Summary
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    Intracoronary Urokinase effectively treated acute myocardial infarction, achieving vessel recanalization in 88% of patients. Successful thrombolysis improved cardiac function, demonstrating Urokinase

    Area of Science:

    • Cardiology
    • Interventional Cardiology
    • Thrombolytic Therapy

    Context:

    • Acute myocardial infarction (AMI) remains a leading cause of mortality.
    • Prompt restoration of coronary blood flow is critical for myocardial salvage.
    • Intracoronary thrombolysis offers a potential therapeutic strategy for AMI.

    Purpose:

    • To evaluate the efficacy and safety of intracoronary Urokinase administration in patients with acute myocardial infarction.
    • To assess the impact of different Urokinase infusion rates on recanalization success.
    • To determine the effect of successful thrombolysis on left ventricular function.

    Summary:

    • Intracoronary Urokinase was administered to 42 patients with acute myocardial infarction.
    • Recanalization of occluded coronary vessels was achieved in 36 patients (88%).

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  • Successful thrombolysis correlated with improved left ventricular ejection fraction in patients with pre-existing depressed function.

    • Impact:

    • Intracoronary Urokinase demonstrates significant efficacy in restoring coronary patency during acute myocardial infarction.
    • The treatment leads to functional cardiac improvement, particularly in patients with compromised left ventricular function.
    • This study supports the use of intracoronary Urokinase as a viable thrombolytic option in managing acute myocardial infarction.